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Hello Visitor,
Please see below some information from the Global Lung Function Initiative (GLI) Network regarding the recently published GLI TLCO reference equations. Although the changes to the predicted values and normal ranges are small, any laboratory currently using the GLI TLCO reference equations will need to consider the impact of these changes and decide how they deal with this issue. This information has been passed on the manufacturers, however it is unknown how long the changes will take to implement.
For those who are not already registered, anybody can register to be part of the GLI Network, so that you will be put onto the mailing list to receive emails regarding any GLI information. This can be done at: https://www.ers-education.org/guidelines/global-lung-function-initiative/about/
Kind regards,
ANZSRS Board
Dear GLI Network,
It was recently brought to our attention that females with low TLco values had exceptionally low z-scores when calculated using the GLI TLCO calculator. We subsequently looked through the models and original data and identified an anomaly which was likely due to a discrepancy in the label that was assigned to sex in one of the datasets (n=282 females; n=259 males). The primary difference is in the predicted values for adult females, and for the calculation of z-scores in adult females; there will be minimal differences in the percent predicted values (average percent predicted change 1.02% (SD 2.0%). Although the differences in males were minimal (average percent predicted change 0.6% (SD 0.4%)), the prediction equations for males also changed in the re-analysis. The error did not impact the overall conclusions regarding corrections for altitude, dead space or the minimal differences observed between equipment and centre.
Although every effort was made to harmonize and clean the data, regrettably this was an error that was missed by our team. We recognize that this will impact on previously calculated values and will make every effort to notify the respiratory community, including the manufacturers, to ensure the updated formulas are implemented. A correction has been published in the European Respiratory Journal https://erj.ersjournals.com/content/50/3/1700010.short and the online GLI calculators www.lungfunction.org have been corrected.
Updated equations and look-up tables are available on the ERJ website and will also be available shortly on www.lungfunction.org
Best wishes,
Sanja
Sanja Stanojevic PhD
Co-Chair GLI Networ
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